A Lethal Change in the Weather: Temperature Extremes and Premature Mortality

in the sample population ranged from 31% to 92% (mean 68%). Two regions of the chromosome arm showed Al values greater than the background range of 10-22% (mean 17%) of informative cases that was observed with five markers spanning 6q21 -q25.2. Firstly, seven markers gave Al values that averaged 35% in a region flanked by D6S313 (Al = 10%) at 6ql3 and D6S283 (Al = 17%) at 6qI6.3-21. The second region showed marginally increased Al at 6q25.2-q27 and included D6S193, previously shown to be close to a tumoursuppressor gene involved in ovarian carcinoma. Since Al of 6q in breast cancer was shown previously to be due predominantly to loss of heterozygosity, our results suggest the presence of at least two tumour-suppressor